It's quite common that you need to remove some software when running in Safe Mode, particularly when you find your system is unusable when running normally. However, by default, the key service required to manage installed software is not running, and cannot be started (the Windows Installer Service, aka MSIServer).

Here is a quick way around this issue - by adding the registry entry below, you'll then be able to start the service and remove / install the software you require.

reg add "HKLM\SYSTEM\CurrentControlSet\Control\SafeBoot\Minimal\MSIServer" /VE /T REG_SZ /F /D "Service"
sc start msiserver`

Once this change is made, it will remain permanent, and you won't need to re-apply it in the future, although you'll still need to start the msiserver service when required.